6-Boc-2-羟基-6-氮杂螺[3.4]辛烷合成路线 （共 2 条）
反应条件
sodium tetrahydroborate in tetrahydrofuran T=0 - 20°C; 6 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BENTZIEN, Joerg Martin; BERRY, Angela Kay; BOSANAC, Todd; BURKE, Michael Jason; DISALVO, Darren Todd; HORAN, Joshua Courtney; LIANG, Shuang; MAO, Can; MAO, Wang; SHEN, Yue; SOLEYMANZADEH, Fariba; ZINDELL, Renee M.
Patent: US2014/45813 A1, 2014 ;
Location in patent: Paragraph 0114 ;
反应条件
1: zinc/copper couple / diethyl ether; ethylene glycol dimethyl ether / 48 h / 10 - 20 °C / |Inert atmosphere 2: zinc; ammonium chloride / methanol / 8 h / 20 °C 3: sodium tetrahydroborate / tetrahydrofuran / 6 h / 0 - 20 °C View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BENTZIEN, Joerg Martin; BERRY, Angela Kay; BOSANAC, Todd; BURKE, Michael Jason; DISALVO, Darren Todd; HORAN, Joshua Courtney; LIANG, Shuang; MAO, Can; MAO, Wang; SHEN, Yue; SOLEYMANZADEH, Fariba; ZINDELL, Renee M.
Patent: US2014/45813 A1, 2014 ;
