1-环丙基-4-碘-1H-吡唑合成路线 （共 3 条）
反应条件
[2,2']bipyridinyl; copper diacetate; sodium carbonate in 1,2-dichloro-ethane T=50 - 70°C;
参考文献
US2011/230462 A1, ;
Page/Page column 84 ;
US 20110230462 A1
反应条件
1: 4-Iodopyrazole With sodium hydride in N,N-dimethyl-formamide; mineral oil T=20°C; 0.25 h; 2: cyclopropyl bromide With tetra-(n-butyl)ammonium iodide in N,N-dimethyl-formamide; mineral oil T=140°C;
参考文献
WO2012/24620 A2, ;
Page/Page column 183 ;
WO 2012/024620 A2
反应条件
1: 1-cyclopropyl-4-iodo-1H-pyrazole With isopropylmagnesium chloride in tetrahydrofuran T=0°C; 0.75 h; 2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran T=0 - 20°C; 1 h;
参考文献
Hendricks, Robert Than; Hermann, Johannes; Kondru, Rama; Lou, Yan; Lynch, Stephen M.; Owens, Timothy D.; Soth, Michael
Patent: US2011/230462 A1, 2011 ;
Location in patent: Page/Page column 84 ;
US 20110230462 A1
