(2S)-N-[(2S)-1-[[(2S)-1-(羟基氨基)-1-氧代丙烷-2-基]氨基]-4-甲基-1-氧代戊烷-2-基]吡咯烷-2-甲酰胺合成路线 （共 3 条）
反应条件
1: triethylamine (TEA), dicyclohexylcarbodiimide (DCC), N-hydroxybenzotriazole (HOBt) / dimethylformamide; CH2Cl2 / 5 °C 2: 81 percent / H2 / 5percent Pd-C / methanol / 1 h / Ambient temperature 3: HCl / ethyl acetate / 1 h View Scheme
参考文献
Odake; Okayama; Obata; Morikawa; Hattori; Hori; Nagai
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 4 p. 1007 - 1011
反应条件
1: triethylamine (TEA), dicyclohexylcarbodiimide (DCC), N-hydroxybenzotriazole (HOBt) / dimethylformamide; CH2Cl2 / 5 °C 2: HCl / ethyl acetate / Ambient temperature 3: triethylamine (TEA), dicyclohexylcarbodiimide (DCC), N-hydroxybenzotriazole (HOBt) / dimethylformamide; CH2Cl2 / 5 °C 4: 81 percent / H2 / 5percent Pd-C / methanol / 1 h / Ambient temperature 5: HCl / ethyl acetate / 1 h View Scheme
参考文献
Odake; Okayama; Obata; Morikawa; Hattori; Hori; Nagai
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 4 p. 1007 - 1011
反应条件
1: HCl / ethyl acetate / Ambient temperature 2: triethylamine (TEA), dicyclohexylcarbodiimide (DCC), N-hydroxybenzotriazole (HOBt) / dimethylformamide; CH2Cl2 / 5 °C 3: 81 percent / H2 / 5percent Pd-C / methanol / 1 h / Ambient temperature 4: HCl / ethyl acetate / 1 h View Scheme
参考文献
Odake; Okayama; Obata; Morikawa; Hattori; Hori; Nagai
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 4 p. 1007 - 1011
