(4-羟基甲基苄基)-氨基甲酸叔丁酯合成路线 （共 23 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; 1,4-dioxane T=0 - 20°C; 16.25 h;
参考文献
CHROMA THERAPEUTICS LTD
Patent: WO2006/117549 A1, 2006 ;
Location in patent: Page/Page column 147 ;
WO 2006/117549 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C;
参考文献
Solladie, Nathalie; Walther, Mathieu E.; Herschbach, Haiko; Leize, Emmanuelle; Dorsselaer, Alain Van; Duarte, Teresa M. Figueira; Nierengarten, Jean-Francois
Tetrahedron, 2006 , vol. 62, # 9 p. 1979 - 1987
反应条件
in dichloromethane T=20°C; 48 h;
参考文献
Lagu, Bharat; Wachter, Michael
Patent: US2006/293379 A1, 2006 ;
Location in patent: Page/Page column 63 ;
US 20060293379 A1
反应条件
1: 4-cyano-benzoic acid With lithium aluminium tetrahydride in tetrahydrofuran T=20 - 60°C; 2: With sodium hydroxide in tetrahydrofuran; water T=-5 - 25°C; 3: di-tert-butyl dicarbonate in tetrahydrofuran; water T=20°C;
参考文献
Khilevich, Albert; Liu, Bin; Mayhugh, Daniel Ray; Schkeryantz, Jeffrey Michael; Zhang, Deyi
Patent: US2010/16373 A1, 2010 ;
Location in patent: Page/Page column 12 ;
反应条件
sodium borohydride; triethylamine in tetrahydrofuran
参考文献
SmithKline Beecham Corporation
Patent: US6403578 B1, 2002 ;
反应条件
1: aq. NaOH / dioxane / 20 °C 2: 86 percent / LiAlH4 / dioxane; tetrahydrofuran View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 10 p. 2411 - 2413
反应条件
1: 90 percent / aq. NaOH / dioxane / 0.67 h / 0 °C 2: 67 percent / BH3*THF / tetrahydrofuran / 20 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 10 p. 1491 - 1508
反应条件
1: hydrogen; nickel; ammonium hydroxide / ethanol / 16 h / 20 °C 2: triethylamine / tetrahydrofuran / 1.5 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 52, # 1 p. 33 - 47
反应条件
1: 91 percent / KOH / H2O; tetrahydrofuran / 20 °C 2: 93 percent / LiAlH4 / tetrahydrofuran / 0 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 15 p. 3043 - 3046
反应条件
1: 91 percent / KOH / H2O; tetrahydrofuran / 20 °C 2: 93 percent / LiAlH4 / tetrahydrofuran / 0 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 15 p. 3043 - 3046
