(4-羟基甲基苄基)-氨基甲酸叔丁酯合成路线 （共 23 条）
反应条件
1.1: hydrogenchloride; water / tetrahydrofuran / 1 h 2.1: hydrogen bromide / dichloromethane; acetic acid 3.1: sodium azide / N,N-dimethyl-formamide / 1 h / 60 °C 4.1: sodium tetrahydroborate; methanol / 1 h / 0 °C 5.1: triphenylphosphine / tetrahydrofuran / 1 h / 60 °C 5.2: Heating 6.1: chloroform / Inert atmosphere View Scheme
反应条件
1.1: sodium tetrahydroborate; methanol / 1 h / 0 °C 2.1: hydrogenchloride; water / tetrahydrofuran / 1 h 3.1: hydrogen bromide / dichloromethane; acetic acid 4.1: sodium azide / N,N-dimethyl-formamide / 1 h / 60 °C 5.1: sodium tetrahydroborate; methanol / 1 h / 0 °C 6.1: triphenylphosphine / tetrahydrofuran / 1 h / 60 °C 6.2: Heating 7.1: chloroform / Inert atmosphere View Scheme
反应条件
1.1: sodium azide / N,N-dimethyl-formamide / 1 h / 60 °C 2.1: sodium tetrahydroborate; methanol / 1 h / 0 °C 3.1: triphenylphosphine / tetrahydrofuran / 1 h / 60 °C 3.2: Heating 4.1: chloroform / Inert atmosphere View Scheme
反应条件
1.1: hydrogen bromide / dichloromethane; acetic acid 2.1: sodium azide / N,N-dimethyl-formamide / 1 h / 60 °C 3.1: sodium tetrahydroborate; methanol / 1 h / 0 °C 4.1: triphenylphosphine / tetrahydrofuran / 1 h / 60 °C 4.2: Heating 5.1: chloroform / Inert atmosphere View Scheme
反应条件
1.1: triphenylphosphine / tetrahydrofuran / 1 h / 60 °C 1.2: Heating 2.1: chloroform / Inert atmosphere View Scheme
反应条件
1.1: sodium tetrahydroborate; methanol / 1 h / 0 °C 2.1: triphenylphosphine / tetrahydrofuran / 1 h / 60 °C 2.2: Heating 3.1: chloroform / Inert atmosphere View Scheme
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 15 h / 0 °C / |Inert atmosphere; |Reflux 2: triethylamine / tetrahydrofuran / 12 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 12 p. 5198 - 5202
反应条件
1: 75 percent / Ph3P; CCl4 / CH2Cl2 / 24 h / 20 °C 2: 83.1 percent / H2O; ethanol / 5 h / Heating 3: conc. HCl / 4 h / Heating 4: 2.57 g / N,N-diisopropylethylamine / H2O; acetonitrile / 1.25 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 1 p. 161 - 175
反应条件
hydrogenchloride in 1,4-dioxane T=50°C; 1 h;
参考文献
Khilevich, Albert; Liu, Bin; Mayhugh, Daniel Ray; Schkeryantz, Jeffrey Michael; Zhang, Deyi
Patent: US2010/16373 A1, 2010 ;
Location in patent: Page/Page column 21 ;
反应条件
phosphorus tribromide in tetrahydrofuran T=-78°C; 2 h;
参考文献
Eli Lilly and Company; Wayne State University; University of Hawaii
Patent: US6680311 B1, 2004 ;
Location in patent: Page/Page column 151 ;
