3,5-二氟-4-(羟基甲基)苯甲酸叔丁酯合成路线 （共 2 条）
反应条件
sodium tetrahydroborate in methanol T=0°C; 0.333333 h;
参考文献
EXELIXIS, INC.; BOLLU, Venkataiah; BOREN, Brant, Clayton; DALGARD, Jackline, Eve; FLATT, Brenton, T.; HAQ, Nadia; HUDSON, Sarah; MOHAN, Raju; MORRISSEY, Michael; PRATT, Benjamin; WANG, Tie-lin
Patent: WO2010/93845 A1, 2010 ;
Location in patent: Page/Page column 151-152 ;
WO 2010/093845 A1
反应条件
1.1: magnesium sulfate; sulfuric acid / toluene / 20 °C 2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C 2.2: 0.5 h / -78 °C 3.1: sodium tetrahydroborate / methanol / 0.33 h / 0 °C View Scheme
参考文献
EXELIXIS, INC.; BOLLU, Venkataiah; BOREN, Brant, Clayton; DALGARD, Jackline, Eve; FLATT, Brenton, T.; HAQ, Nadia; HUDSON, Sarah; MOHAN, Raju; MORRISSEY, Michael; PRATT, Benjamin; WANG, Tie-lin
Patent: WO2010/93845 A1, 2010 ;
WO 2010/093845 A1
