反应条件
1: 91 percent / CH2Cl2 / 16 h / Ambient temperature
2: 77 percent / Na, liq. NH3 / tetrahydrofuran; ethanol / 3 h / -33 °C
3: 60 percent / I2, chlorodiphenylphosphine, imidazole / toluene / 3 h / 70 °C
4: 1.) n-BuLi, 2.) HMPA / 1.) THF, hexane, from -78 deg C to RT, 1 h, 2.) THF, hexane, form -78 deg C to RT, 4 h
5: 68 percent / methanolic para-toluenesulfonic acid / toluene / 144 h
6: 88 percent / H2 / 10percent Pd/C / diethyl ether / 16 h
7: 44 percent / molecular sieves 4 A, pyridinum dichromate / dimethylformamide / 120 h / Ambient temperature
8: 94 percent / 10percent aq. tetrabutylammonium hydroxide / CH2Cl2 / 16 h
View Scheme
参考文献
Wallace, Paul A.; Minnikin, David E.; McCrudden, Katharine; Pizzarello, Andrea
Chemistry and Physics of Lipids, 1994 , vol. 71, # 2 p. 145 - 162
