1: 4-bromo-4'-tert-butylbiphenyl With magnesium in tetrahydrofuran Grignard reaction; Reflux; 2: carbon dioxide in tetrahydrofuran 3: With hydrogenchloride in tetrahydrofuran; water
potassium tert-butylate; lithium; methyl iodide 1.) THF, -75 deg C, 2.) 10.5 min; the other reagent and time; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Grovenstein, Erling; Lu, Pang-Chia
Journal of Organic Chemistry, 1982 , vol. 47, # 15 p. 2928 - 2939
1: With copper(l) iodide; 5,5-bis(4,5-dihydrooxazol-2-yl)nonane; cesium fluoride in N,N-dimethyl-formamide T=90°C; P=760.051 Torr; 10 h; 2: With hydrogenchloride; water in N,N-dimethyl-formamide
