tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
heating in autoclave pressurized with CO2 (33 atm) at 70°C for 24h; cooling, releasing of the pressure, removal of the solvent; chromatography;
参考文献
Shi; Nicholas
Journal of the American Chemical Society, 1997 , vol. 119, # 21 p. 5057 - 5058
1: 2-chloro-4-fluoro-1-methoxy-benzene With n-butyllithium in tetrahydrofuran
T=-70°C; 1.5 h;
2: carbon dioxide in tetrahydrofuran
T=-70°C; 0.166667 h;
3: With hydrogenchloride; sodium hydroxide
more than 3 stages;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2006/77414 A1, 2006 ;
Location in patent: Page/Page column 149 ;
WO 2006/077414 A1
1: 4-chloro-2-fluoro-1-methoxybenzene With n-butyllithium in tetrahydrofuran
T=-78°C; 0.5 h;
2: carbon dioxide in tetrahydrofuran
T=-78 - 20°C;
3: With hydrogenchloride; water
pH=~ 1;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/71736 A1, 2008 ;
Location in patent: Page/Page column 54 ;
WO 2008/071736 A1
Costa, Ana M. B. S. R. C. S.; Dean, Francis M.; Jones, Michael A.; Smith, Dennis A.
Journal of the Chemical Society, Chemical Communications, 1983 , # 19 p. 1098 - 1099
Costa, Ana M. B. S. R. C. S.; Dean, Francis M.; Jones, Michael A.; Smith, Dennis A.
Journal of the Chemical Society, Chemical Communications, 1983 , # 19 p. 1098 - 1099
