1: ethyl (R)-(+)-2-fluoroacetate; formic acid ethyl ester With sodium hydride in tetrahydrofuran T=0 - 20°C; 72 h; 2: 1-Imino-ethanamine hydrochloride With sodium ethanolate in ethanol Heating / reflux; 3: With hydrogenchloride in water pH=6;
参考文献
PFIZER INC.
Patent: WO2008/96260 A1, 2008 ;
Location in patent: Page/Page column 40 ;
WO 2008/096260 A1