1.1: triethylamine; hydrogen / palladium 10 on activated carbon / tetrahydrofuran / 1 h / 20 °C / 760.05 Torr 2.1: 1H-imidazole / dichloromethane / 18 h / 20 °C 3.1: diisobutylaluminium hydride / dichloromethane; hexane / 0.5 h / -30 °C / Inert atmosphere 3.2: -30 °C 4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 4.2: 3.25 h / 0 - 20 °C 5.1: hydrogenchloride / water; tetrahydrofuran / 18 h / 20 °C 5.2: pH 6.8 / Aqueous phosphate buffer View Scheme

1.1: triethylamine; hydrogen / palladium 10 on activated carbon / tetrahydrofuran / 1 h / 20 °C / 760.05 Torr 2.1: 1H-imidazole / dichloromethane / 18 h / 20 °C 3.1: diisobutylaluminium hydride / dichloromethane; hexane / 0.5 h / -30 °C / Inert atmosphere 3.2: -30 °C 4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 4.2: 3.25 h / 0 - 20 °C 5.1: hydrogenchloride / water; tetrahydrofuran / 18 h / 20 °C 5.2: pH 6.8 / Aqueous phosphate buffer 6.1: Novozym 435 / 18 h / 30 °C View Scheme

1.1: 1H-imidazole / dichloromethane / 18 h / 20 °C 2.1: diisobutylaluminium hydride / dichloromethane; hexane / 0.5 h / -30 °C / Inert atmosphere 2.2: -30 °C 3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 3.2: 3.25 h / 0 - 20 °C 4.1: potassium carbonate / acetone / 18 h / 20 °C 5.1: water / tetrahydrofuran / 52 h / 20 °C 6.1: hydrogenchloride / water; tetrahydrofuran / 18 h / 20 °C 6.2: pH 6.8 / Aqueous phosphate buffer View Scheme