N-Boc-3-(甲基氨基)丙酸合成路线 （共 6 条）
反应条件
sodium hydride in tetrahydrofuran; mineral oil T=0 - 20°C;
参考文献
GRÜNENTHAL GMBH; SCHUNK, Stefan; REICH, Melanie; STEINHAGEN, Henning; DAMANN, Nils; SKONE, Philip; HAMLYN, Richard; KIRBY, Robert; ROGERS, Marc; SUTTON, Kathy
Patent: WO2014/32801 A1, 2014 ;
Location in patent: Page/Page column 157 ;
反应条件
1: With lithium hydroxide; water in methanol 5 h; 2: With citric acid in water
参考文献
SHIONOGI and CO., LTD.
Patent: EP1422218 A1, 2004 ;
Location in patent: Page 86 ;
反应条件
1: in tetrahydrofuran; water T=20°C; 24 h; 2: With hydrogenchloride in water T=0°C; pH=4;
参考文献
WO2008/156831 A2, ;
Page/Page column 73 ;
WO 2008/156831 A2
反应条件
sodium hydroxide in ethanol; water T=20°C;
参考文献
Lv, Jinglei; Li, Ji; Zhang-Negrerie, Daisy; Shang, Siyun; Gao, Qingzhi; Du, Yunfei; Zhao, Kang
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 12 p. 1929 - 1932
反应条件
in 1,4-dioxane; water T=20°C; Reflux;
参考文献
EP2141166 A1, ;
Page/Page column 15-16 ;
反应条件
1: 70 percent / EDC*HCl; DMAP / CH2Cl2 / 0 - 20 °C 2: aq. HCOOH / 20 °C View Scheme
参考文献
Ogawa, Tadashi; Araki, Mamoru; Miyamae, Tetsuhisa; Okayama, Toru; Hagiwara, Masaki; Sakurada, Shinobu; Morikawa, Tadanori
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 7 p. 759 - 771
