1: diethyl ether 2: 98 percent / K2CO3 / 6 h / Ambient temperature 3: 94 percent / Ph3P, diethylazodicarboxylate / tetrahydrofuran / 2 h / Ambient temperature View Scheme

1: 98 percent / K2CO3 / 6 h / Ambient temperature 2: 94 percent / Ph3P, diethylazodicarboxylate / tetrahydrofuran / 2 h / Ambient temperature View Scheme

1: 83 percent / diethyl phosphorocyanidate, Et3N / dimethylformamide / 2 h / 0 °C 2: 100 percent / aq. KOH / methanol / 10 h / Heating 3: 87 percent / NBS / dimethylformamide / 24 h / Ambient temperature 4: 6N aq. HCl / 12 h / Heating 5: diethyl ether 6: 98 percent / K2CO3 / 6 h / Ambient temperature 7: 94 percent / Ph3P, diethylazodicarboxylate / tetrahydrofuran / 2 h / Ambient temperature View Scheme

1: 100 percent / aq. KOH / methanol / 5 h / Heating 2: 83 percent / diethyl phosphorocyanidate, Et3N / dimethylformamide / 2 h / 0 °C 3: 100 percent / aq. KOH / methanol / 10 h / Heating 4: 87 percent / NBS / dimethylformamide / 24 h / Ambient temperature 5: 6N aq. HCl / 12 h / Heating 6: diethyl ether 7: 98 percent / K2CO3 / 6 h / Ambient temperature 8: 94 percent / Ph3P, diethylazodicarboxylate / tetrahydrofuran / 2 h / Ambient temperature View Scheme

1: 87 percent / NBS / dimethylformamide / 24 h / Ambient temperature 2: 6N aq. HCl / 12 h / Heating 3: diethyl ether 4: 98 percent / K2CO3 / 6 h / Ambient temperature 5: 94 percent / Ph3P, diethylazodicarboxylate / tetrahydrofuran / 2 h / Ambient temperature View Scheme

1: 6N aq. HCl / 12 h / Heating 2: diethyl ether 3: 98 percent / K2CO3 / 6 h / Ambient temperature 4: 94 percent / Ph3P, diethylazodicarboxylate / tetrahydrofuran / 2 h / Ambient temperature View Scheme

1: 100 percent / aq. KOH / methanol / 10 h / Heating 2: 87 percent / NBS / dimethylformamide / 24 h / Ambient temperature 3: 6N aq. HCl / 12 h / Heating 4: diethyl ether 5: 98 percent / K2CO3 / 6 h / Ambient temperature 6: 94 percent / Ph3P, diethylazodicarboxylate / tetrahydrofuran / 2 h / Ambient temperature View Scheme

1: 49 percent / t-butylhydroperoxide, titanium isopropoxide, diethyl L-(+)-tartrate / -20 deg C, 3 h. then room temp., 1 h. 2: 1.) NaIO4; 2.) NaHCO3 / 1.) RuCl3 / 1.) CCl4, CH3CN, H2O, room temp., 7 h.; 2.) DMF, room temp. View Scheme

sodium periodate; sodium hydrogencarbonate; ruthenium trichloride 1.) CCl4, CH3CN, H2O, room temp., 7 h.; 2.) DMF, room temp.; Yield given. Multistep reaction;