1-(4-溴苯基)环丙烷甲腈合成路线 （共 10 条）
反应条件
N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide in water T=50°C; 22 h;
参考文献
WO2013/189865 A1, ;
Page/Page column 27 ;
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in water T=20°C;
参考文献
US6359135 B1, ;
Page column 113 ;
反应条件
sodium hydroxide in water
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in water T=20°C;
参考文献
US6369225 B1, ;
Page column 41-42, 112 ;
反应条件
potassium carbonate T=145 - 150°C; 1 h;
参考文献
Tetrahedron Letters, , vol. 46, # 42 p. 7247 - 7248
反应条件
1: With potassium hydroxide in water; ethylene glycol T=135 - 140°C; 4 h; 2: With hydrogenchloride in water
参考文献
US6359135 B1, ;
Page column 113 ;
反应条件
potassium hydroxide in water T=135 - 140°C; 4 h;
参考文献
US6369261 B1, ;
Page column 111 ;
反应条件
1.1: potassium hydroxide / ethylene glycol / 4 h / 180 °C 1.2: Acidic conditions 2.1: sulfuric acid / 1 h / 75 °C 3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere View Scheme
参考文献
AMIRA PHARMACEUTICALS, INC.; BRISTOL-MYERS SQUIBB COMPANY; BRITTAIN, Jason, Edward; SEIDERS, Thomas, Jon; HUTCHINSON, John, Howard; KING, Christopher, David; ROSSO, Victor, W.
Patent: WO2012/78805 A1, 2012 ;
WO 2012/078805 A1
反应条件
1.1: potassium hydroxide / ethylene glycol / 4 h / 180 °C 1.2: Acidic conditions 2.1: sulfuric acid / 1 h / 75 °C View Scheme
参考文献
AMIRA PHARMACEUTICALS, INC.; BRISTOL-MYERS SQUIBB COMPANY; BRITTAIN, Jason, Edward; SEIDERS, Thomas, Jon; HUTCHINSON, John, Howard; KING, Christopher, David; ROSSO, Victor, W.
Patent: WO2012/78805 A1, 2012 ;
WO 2012/078805 A1
反应条件
sulfuric acid; sodium bromide in acetic acid
T=70°C; 3 h;
参考文献
Wacker, Sarah A.; Kashyap, Sudhir; Li, Xiang; Kapoor, Tarun M.
Journal of the American Chemical Society, 2011 , vol. 133, # 32 p. 12386 - 12389
