1-(3-溴-苯基)-环丙烷甲腈合成路线 (共 5 条)
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in water T=10 - 55°C; 20 h;
参考文献
Boehringer Ingelheim Pharma GmbH and Co.KG
Patent: EP1206446 B1, 2004 ;
Location in patent: Page 11 ;
反应条件
N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide in water T=20°C;
参考文献
Santen Pharmaceutical Co., Ltd
Patent: EP2119703 A1, 2009 ;
Location in patent: Page/Page column 34-35 ;
反应条件
1: With water; potassium hydroxide in ethylene glycol T=140°C; 4.5 h; 2: in ethylene glycol
参考文献
Boehringer Ingelheim Pharma GmbH and Co.KG
Patent: EP1206446 B1, 2004 ;
Location in patent: Page 12 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -100 °C / |Inert atmosphere
1.2: 2 h / -100 - 20 °C / |Inert atmosphere
2.1: palladium diacetate; N-acetyl-glycine; silver(I) acetate / 1,2-dichloro-ethane / 24 h / 90 °C / |Inert atmosphere
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参考文献
Lee, Sunggi; Lee, Hyelee; Tan, Kian L.
Journal of the American Chemical Society, 2013 , vol. 135, # 50 p. 18778 - 18781
反应条件
potassium hydroxide; dihydrogen peroxide in methanol; water
T=55°C; 5 h;
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: WO2004/821 A1, 2003 ;
Location in patent: Page 28 ;