3-溴-5-(溴甲基)苯甲腈合成路线 (共 6 条)
反应条件
N-bromosuccinmide in benzene T=80°C; Rate constant;
参考文献
Glaxo Group Limited
Patent: US2009/203657 A1, 2009 ;
Location in patent: Page/Page column 53-54 ;
US 20090203657 A1
反应条件
1.1: dibenzoyl peroxide; 1,3-dibromo-5,5-dimethyl-hydantoin / tetrachloromethane / 7 h / Reflux 2.1: calcium carbonate / 1,4-dioxane; water / 16 h / Reflux 3.1: potassium permanganate / water; acetone / 1 h / Reflux 4.1: 1,1'-carbonyldiimidazole / ethyl acetate / 3 h / Reflux 4.2: 1 h / 20 °C 5.1: phosphorous pentoxide / chloroform / 48 h / Reflux 6.1: dibenzoyl peroxide; N-bromosuccinmide / tetrachloromethane / 10 h / Reflux View Scheme
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/100169 A1, 2009 ;
WO 2009/100169 A1
反应条件
1.1: 1,1'-carbonyldiimidazole / ethyl acetate / 3 h / Reflux 1.2: 1 h / 20 °C 2.1: phosphorous pentoxide / chloroform / 48 h / Reflux 3.1: dibenzoyl peroxide; N-bromosuccinmide / tetrachloromethane / 10 h / Reflux View Scheme
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/100169 A1, 2009 ;
WO 2009/100169 A1
反应条件
1.1: calcium carbonate / 1,4-dioxane; water / 16 h / Reflux 2.1: potassium permanganate / water; acetone / 1 h / Reflux 3.1: 1,1'-carbonyldiimidazole / ethyl acetate / 3 h / Reflux 3.2: 1 h / 20 °C 4.1: phosphorous pentoxide / chloroform / 48 h / Reflux 5.1: dibenzoyl peroxide; N-bromosuccinmide / tetrachloromethane / 10 h / Reflux View Scheme
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/100169 A1, 2009 ;
WO 2009/100169 A1
反应条件
1.1: potassium permanganate / water; acetone / 1 h / Reflux 2.1: 1,1'-carbonyldiimidazole / ethyl acetate / 3 h / Reflux 2.2: 1 h / 20 °C 3.1: phosphorous pentoxide / chloroform / 48 h / Reflux 4.1: dibenzoyl peroxide; N-bromosuccinmide / tetrachloromethane / 10 h / Reflux View Scheme
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/100169 A1, 2009 ;
WO 2009/100169 A1
反应条件
1: phosphorous pentoxide / chloroform / 48 h / Reflux 2: dibenzoyl peroxide; N-bromosuccinmide / tetrachloromethane / 10 h / Reflux View Scheme
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/100169 A1, 2009 ;
WO 2009/100169 A1