1: 63 percent / methanol / 0.5 h / 50 °C 2: 76 percent / 2N NaOH / 5 h / 100 °C View Scheme

1: 70 percent / H2S, NEt3, pyridine / 0.5 h / Ambient temperature 2: 75 percent / 2N NaOH / dimethylformamide / 0.5 h / Ambient temperature 3: 46 percent / dimethylsulfoxide / 14 h / 170 °C View Scheme

<b>Multi-step reaction with 4 steps<br /> </b>1: 100 percent / hydrazine hydrate / acetic acid / 3 h / 100 &deg;C<br />2: 58 percent / dimethylformamide / 2.5 h / 100 &deg;C<br />3: 67 percent / SnCl₂*2H₂O; conc. HCl / dimethylformamide / 0.5 h / 5 - 10 &deg;C<br />4: 82 percent / CF₃COOH / 1 h / 80 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 58 percent / dimethylformamide / 2.5 h / 100 &deg;C<br />2: 67 percent / SnCl₂*2H₂O; conc. HCl / dimethylformamide / 0.5 h / 5 - 10 &deg;C<br />3: 82 percent / CF₃COOH / 1 h / 80 &deg;C<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '742035', constants.ctx, '0')">trifluoroacetic acid</a> <br />T=80&deg;C;&nbsp;1&nbsp;h;&nbsp;<br /> &nbsp;