1.1: triphenylphosphine; water / tetrahydrofuran / 50 °C
1.2: 0.08 h / 20 °C
2.1: sodium hydrogencarbonate; sodium hydroxide / water / pH 9
View Scheme
参考文献
PFIZER INC.; AM ENDE, Christopher William; JOHNSON, Douglas Scott; O'DONNELL, Christopher John; PETTERSSON, Martin Youngjin; SUBRAMANYAM, Chakrapani
Patent: WO2011/48525 A1, 2011 ;
WO 2011/048525 A1
1: With triphenylphosphine in tetrahydrofuran; water
T=50°C; Inert atmosphere;
2: With hydrogenchloride in tetrahydrofuran; 1,4-dioxane; water
T=20°C; 0.0833333 h; Inert atmosphere;
参考文献
PFIZER INC.; AM ENDE, Christopher William; JOHNSON, Douglas Scott; O'DONNELL, Christopher John; PETTERSSON, Martin Youngjin; SUBRAMANYAM, Chakrapani
Patent: WO2011/48525 A1, 2011 ;
Location in patent: Page/Page column 48-49 ;
WO 2011/048525 A1
