2-吡啶-4-基-3H-苯并咪唑-4-羧酸合成路线 （共 9 条）
反应条件
in N,N-dimethyl-formamide T=80°C; 120 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 8 p. 2641 - 2649
反应条件
1: NaOH; hydrazine hydrate; Raney Ni 2: K3Fe(CN)6 / methanol / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 2 p. 267 - 269
反应条件
1: aq. KOH / Heating 2: H2, aq. NaOH / Pd/C 3: cupric acetate, AcOH / H2O; methanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 2 p. 814 - 819
反应条件
1: SOCl2 / 1 h / Heating 2: aq. NaN3 / acetone / 1 h / below 25 deg C 3: aq. AcOH / 0.17 h / Heating 4: aq. KOH / Heating 5: H2, aq. NaOH / Pd/C 6: cupric acetate, AcOH / H2O; methanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 2 p. 814 - 819
反应条件
1: aq. NaN3 / acetone / 1 h / below 25 deg C 2: aq. AcOH / 0.17 h / Heating 3: aq. KOH / Heating 4: H2, aq. NaOH / Pd/C 5: cupric acetate, AcOH / H2O; methanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 2 p. 814 - 819
反应条件
1: aq. AcOH / 0.17 h / Heating 2: aq. KOH / Heating 3: H2, aq. NaOH / Pd/C 4: cupric acetate, AcOH / H2O; methanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 2 p. 814 - 819
反应条件
1: aq. KOH; Br2 / 80 °C 2: NaOH; hydrazine hydrate; Raney Ni 3: K3Fe(CN)6 / methanol / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 2 p. 267 - 269
反应条件
1: ammonia; water / 0 °C 2: sodium hypochlorite; water; sodium hydroxide / 0 - 80 °C 3: hydrazine hydrate; sodium hydroxide / methanol / Reflux 4: N,N-dimethyl-formamide / 120 h / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 8 p. 2641 - 2649
反应条件
1: acetic anhydride / Reflux 2: ammonia; water / 0 °C 3: sodium hypochlorite; water; sodium hydroxide / 0 - 80 °C 4: hydrazine hydrate; sodium hydroxide / methanol / Reflux 5: N,N-dimethyl-formamide / 120 h / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 8 p. 2641 - 2649
