1: 5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydro thieno [3,2-c] pyridine hydrobromide With triethylamine in dichloromethane T=25 - 30°C; 0.25 h; 2: acetic anhydride in dichloromethane T=0 - 5°C; 6 h;

1: sodium hydrogencarbonate / water / 0.5 h / 10 - 15 °C 2: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C View Scheme

sodium hydrogencarbonate in water T=10 - 15°C; 0.5 h;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 &deg;C<br />2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 &deg;C<br />2.2: 1 h / -78 &deg;C<br />2.3: 1 h / -60 - 0 &deg;C<br />3.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 &deg;C<br /> <br /> &nbsp;