1: AgNO3 / dioxane; H2O / 18 h / Ambient temperature 2: aq. KOH / dioxane / 20 h / Ambient temperature 3: 98 percent / aq. KMnO4 / acetone / 4 h / Ambient temperature 4: 88 percent / polyphosphoric acid / 5 h / 160 °C 5: 14 percent / Et3SiH / trifluoroacetic acid / 48 h / Ambient temperature View Scheme

1: AgNO3 / dioxane; H2O / 18 h / Ambient temperature 2: aq. KOH / dioxane / 20 h / Ambient temperature 3: 98 percent / aq. KMnO4 / acetone / 4 h / Ambient temperature View Scheme

1: AgNO3 / dioxane; H2O / 18 h / Ambient temperature 2: aq. KOH / dioxane / 20 h / Ambient temperature 3: 98 percent / aq. KMnO4 / acetone / 4 h / Ambient temperature 4: 88 percent / polyphosphoric acid / 5 h / 160 °C View Scheme

1: AgNO3 / dioxane; H2O / 18 h / Ambient temperature 2: aq. KOH / dioxane / 20 h / Ambient temperature 3: 98 percent / aq. KMnO4 / acetone / 4 h / Ambient temperature 4: 88 percent / polyphosphoric acid / 5 h / 160 °C 5: 73 percent / Et3SiH / trifluoroacetic acid / 48 h / Ambient temperature View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 2.) 2 M aq. Na₂CO₃ / 1.) Pd(PPh₃)4 / 1.) EtOH, DME, 10 min, 2.) reflux, 20 h<br />2: 76 percent / NBS / benzoyl peroxide / CCl₄ / 36 h / Heating<br /> <br /> &nbsp;