(S)-1-CBZ-3-羟甲基吡咯烷合成路线 （共 10 条）
反应条件
potassium carbonate in tetrahydrofuran T=0°C; 4 h;
参考文献
Mazzini; Lebreton; Alphand; Furstoss
Journal of Organic Chemistry, 1997 , vol. 62, # 15 p. 5215 - 5218
反应条件
1: (1R,3S)-5-oxo-1-(1-phenyl-ethyl)-pyrrolidine-3-carboxylic acid methyl ester With lithium aluminium tetrahydride in tetrahydrofuran Heating; 2: With hydrogen; palladium dihydroxide in methanol T=20°C; 3: benzyl chloroformate With potassium carbonate in tetrahydrofuran; water T=0°C; Further stages.;
参考文献
Tetrahedron Letters, , vol. 48, # 33 p. 5727 - 5730
反应条件
1: 95 percent / H2 / Pd/C / ethanol / 24 h 2: 90 percent / aq. K2CO3 / tetrahydrofuran / 4 h / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 15 p. 5215 - 5218
反应条件
1: 95 percent / LAH / tetrahydrofuran / 0 deg C to reflux 2: 95 percent / DMAP, Et3N / CH2Cl2 / 0.5 h / 0 °C 3: 85 percent / Et3N / dioxane / 12 h / Heating 4: 95 percent / H2 / Pd/C / methanol / 24 h 5: 95 percent / H2 / Pd/C / ethanol / 24 h 6: 90 percent / aq. K2CO3 / tetrahydrofuran / 4 h / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 15 p. 5215 - 5218
反应条件
1: 95 percent / DMAP, Et3N / CH2Cl2 / 0.5 h / 0 °C 2: 85 percent / Et3N / dioxane / 12 h / Heating 3: 95 percent / H2 / Pd/C / methanol / 24 h 4: 95 percent / H2 / Pd/C / ethanol / 24 h 5: 90 percent / aq. K2CO3 / tetrahydrofuran / 4 h / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 15 p. 5215 - 5218
反应条件
1: 85 percent / Et3N / dioxane / 12 h / Heating 2: 95 percent / H2 / Pd/C / methanol / 24 h 3: 95 percent / H2 / Pd/C / ethanol / 24 h 4: 90 percent / aq. K2CO3 / tetrahydrofuran / 4 h / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 15 p. 5215 - 5218
反应条件
1: 95 percent / H2 / Pd/C / methanol / 24 h 2: 95 percent / H2 / Pd/C / ethanol / 24 h 3: 90 percent / aq. K2CO3 / tetrahydrofuran / 4 h / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 15 p. 5215 - 5218
反应条件
1.1: methanol / 100 °C 2.1: LiAlH4 / tetrahydrofuran / Heating 2.2: H2 / Pd(OH)2/C / methanol / 20 °C 2.3: K2CO3 / tetrahydrofuran; H2O / 0 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 48, # 33 p. 5727 - 5730
参考文献
Heterocycles, , vol. 28, # 1 p. 283 - 294
反应条件
chromium(VI) oxide in acetone T=0°C;
参考文献
Mazzini; Lebreton; Alphand; Furstoss
Journal of Organic Chemistry, 1997 , vol. 62, # 15 p. 5215 - 5218
