hydrogenchloride in ethanol; water T=90°C; 6 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '8128150', constants.ctx, '0')">sodium hydroxide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />T=60&deg;C;&nbsp;Smiles rearrangement;&nbsp;2&nbsp;h;&nbsp;&nbsp;Inert atmosphere;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1.1: lithium diisopropyl amide / tetrahydrofuran / -78 &deg;C<br />2.1: sodium hydroxide / ethanol / Reflux<br />3.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 &deg;C / Inert atmosphere<br />3.2: 2 h / 20 &deg;C / Inert atmosphere<br />4.1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 60 &deg;C / Inert atmosphere<br /> <br /> &nbsp;