sodium hydroxide in N,N-dimethyl-formamide T=140°C; 56 h; Inert atmosphere;

<b>Multi-step reaction with 5 steps<br /> </b>1.1: lithium diisopropyl amide / tetrahydrofuran / -78 &deg;C<br />2.1: sodium hydroxide / ethanol / Reflux<br />3.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 &deg;C / Inert atmosphere<br />3.2: 2 h / 20 &deg;C / Inert atmosphere<br />4.1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 60 &deg;C / Inert atmosphere<br />5.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / N,N-dimethyl-formamide / 3 h / 40 &deg;C / Inert atmosphere<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11323889', constants.ctx, '0')">bis-triphenylphosphine-palladium(II) chloride</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '11405916', constants.ctx, '0')">copper(l) iodide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605268', constants.ctx, '0')">diethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />T=40&deg;C;&nbsp;Sonogashira coupling;&nbsp;3&nbsp;h;&nbsp;&nbsp;Inert atmosphere;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1.1: t-Bu₂Zn(tmp)Li / tetrahydrofuran / -30 &deg;C<br />2.1: boron tribromide / dichloromethane / -78 - 20 &deg;C<br />2.2: 0 - 20 &deg;C<br />3.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 &deg;C / Inert atmosphere<br />3.2: 2 h / 20 &deg;C / Inert atmosphere<br />4.1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 60 &deg;C / Inert atmosphere<br />5.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / N,N-dimethyl-formamide / 3 h / 40 &deg;C / Inert atmosphere<br /> <br /> &nbsp;