1: With water; sodium hydroxide T=50°C; 2 h; 2: With hydrogenchloride in water T=20 - 25°C; pH=4;

Multi-step reaction with 4 steps 1.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl / toluene / 16 h / Reflux1.2: 0.17 h1.3: 1 h / 10 - 15 °C2.1: water; lithium hydroxide hydrate / water / 3 h / 50 °C2.2: 20 °C / pH 6 - 6.53.1: 4-(N,N-dimethlyamino)pyridine; pyridine / dichloromethane / 30 - 50 °C4.1: triethylamine; phenylphosphoric acid dichloride / dichloromethane / 0 - 20 °C / Inert atmosphere  

Multi-step reaction with 3 steps 1.1: water; lithium hydroxide hydrate / water / 3 h / 50 °C1.2: 20 °C / pH 6 - 6.52.1: 4-(N,N-dimethlyamino)pyridine; pyridine / dichloromethane / 30 - 50 °C3.1: triethylamine; phenylphosphoric acid dichloride / dichloromethane / 0 - 20 °C / Inert atmosphere  

Multi-step reaction with 3 steps 1.1: sodium hydroxide; water / 20 °C1.2: pH 6 - 6.52.1: 4-(N,N-dimethlyamino)pyridine; pyridine / dichloromethane / 30 - 50 °C3.1: triethylamine; phenylphosphoric acid dichloride / dichloromethane / 0 - 20 °C / Inert atmosphere