7-(哌嗪-1-基)-2-(吡啶-3-基)噻唑并[5,4-d]嘧啶-5-胺合成路线 （共 5 条）
反应条件
1,1,1,3,3,3-hexamethyl-disilazane in pyridine T=150°C; 0.5 h; microwave oven;
参考文献
Katholieke Universiteit Leuven, K.U. Leuven RandD; Herman, Jean; Louat, Thierry
Patent: US2014/88088 A1, 2014 ;
Location in patent: Paragraph 1062-1063 ;
反应条件
1: in dimethyl sulfoxide T=150°C; 1 h; 2: With trifluoroacetic acid in dichloromethane T=20°C; 3: With sodium hydroxide in water
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN RandD; De Jonghe, Steven; Gao, Ling-Jie; Herdewijn, Piet; Herman, Jean; Jang, Miyeon; Leyssen, Pieter; Louat, Thierry; Neyts, Johan; Pannecouque, Christophe; Vanderhoydonck, Bart
Patent: US2013/190297 A1, 2013 ;
Location in patent: Paragraph 1134; 1135; 1136 ;
反应条件
1: sodium sulfide nonahydrate / dimethyl sulfoxide / 50 °C 2: dimethyl sulfoxide / 1 h / 150 °C 3: trifluoroacetic acid / dichloromethane / 20 °C View Scheme
参考文献
Katholieke Universiteit Leuven, K.U. Leuven RandD; Herman, Jean; Louat, Thierry
Patent: US2014/88088 A1, 2014 ;
反应条件
1: dimethyl sulfoxide / 1 h / 150 °C 2: trifluoroacetic acid / dichloromethane / 20 °C View Scheme
参考文献
Jang, Mi-Yeon; Lin, Yuan; De Jonghe, Steven; Gao, Ling-Jie; Vanderhoydonck, Bart; Froeyen, Mathy; Rozenski, Jef; Herman, Jean; Louat, Thierry; Van Belle, Kristien; Waer, Mark; Herdewijn, Piet
Journal of Medicinal Chemistry, 2011 , vol. 54, # 2 p. 655 - 668
反应条件
in 1,4-dioxane T=20°C; 0.5 h;
参考文献
US2012/46278 A1, ;
Page/Page column 71 ;
