4-[5-氨基-2-(吡啶-3-基)噻唑并[5,4-d]嘧啶-7-基]-N-(对甲苯基)哌嗪-1-甲酰胺合成路线 (共 5 条)
反应条件
in 1,4-dioxane T=20°C; 0.5 h;
参考文献
US2012/46278 A1, ;
Page/Page column 71 ;
反应条件
1: 1,1,1,3,3,3-hexamethyl-disilazane / pyridine / 0.5 h / 150 °C / microwave oven 2: 1,4-dioxane / 0.5 h / 20 °C View Scheme
反应条件
1.1: Na2S*9H2O / dimethyl sulfoxide / 50 °C 2.1: dimethyl sulfoxide / 1 h / 150 °C 2.2: 20 °C 3.1: 1,4-dioxane / 0.5 h / 20 °C View Scheme
反应条件
1: trifluoroacetic acid / dichloromethane / 20 °C 2: 1,4-dioxane / 0.5 h / 20 °C View Scheme
反应条件
1.1: dimethyl sulfoxide / 1 h / 150 °C 1.2: 20 °C 2.1: 1,4-dioxane / 0.5 h / 20 °C View Scheme