反应条件
Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '108667', constants.ctx, '0')">4-bromo-2-chloro-pyridine</a> <b>With</b> <a href="#" onclick="return RXDsubstances(event, this, '1209227', constants.ctx, '0')">n-butyllithium</a> <b>in</b> <a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a>; <a href="#" onclick="return RXDsubstances(event, this, '1730733', constants.ctx, '0')">hexane</a> <br />T=-78°C; 0.25 h; Inert atmosphere; <br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '505984', constants.ctx, '0')">acetaldehyde</a> <b>in</b> <a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a>; <a href="#" onclick="return RXDsubstances(event, this, '1730733', constants.ctx, '0')">hexane</a> <br />0.166667 h; <br /> <br />
参考文献
AMGEN INC.; ASHTON, Kate; BARTBERGER, Michael D.; BOURBEAU, Matthew Paul; CROGHAN, Michael D.; FOTSCH, Christopher H.; HUNGATE, Randall W.; KONG, Ke; NISHIMURA, Nobuko; NORMAN, Mark H.; PENNINGTON, Lewis D.; REICHELT, Andreas; SIEGMUND, Aaron C.; TADESSE, Seifu; ST. JEAN, David Jr; YANG, Kevin C.; YAO, Guomin Patent: WO2013/173382 A1, 2013 ; Location in patent: Page/Page column 115 ;
