(Z)-N-羟基-3-(咪唑并[1,2-b]吡嗪-2-基)苯酰胺合成路线 （共 4 条）
反应条件
hydroxylamine hydrochloride; triethylamine in ethanol 4 h; Heating / reflux;
参考文献
HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DENG, Wei; CAI, Yu; DUAN, Jifeng
Patent: WO2011/137587 A1, 2011 ;
Location in patent: Page/Page column 39 ;
反应条件
1: bromine / diethyl ether / 4 h / 0 - 20 °C 2: ethanol / 10 h / Reflux 3: hydrogen / palladium 10 on activated carbon / tetrahydrofuran; methanol / 5 h / 20 °C 4: hydroxylamine hydrochloride; triethylamine / ethanol / 4 h / Reflux View Scheme
参考文献
HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DENG, Wei; CAI, Yu; DUAN, Jifeng
Patent: WO2011/137587 A1, 2011 ;
反应条件
1: ethanol / 10 h / Reflux 2: hydrogen / palladium 10 on activated carbon / tetrahydrofuran; methanol / 5 h / 20 °C 3: hydroxylamine hydrochloride; triethylamine / ethanol / 4 h / Reflux View Scheme
参考文献
HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DENG, Wei; CAI, Yu; DUAN, Jifeng
Patent: WO2011/137587 A1, 2011 ;
反应条件
1: hydrogen / palladium 10 on activated carbon / tetrahydrofuran; methanol / 5 h / 20 °C 2: hydroxylamine hydrochloride; triethylamine / ethanol / 4 h / Reflux View Scheme
参考文献
HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DENG, Wei; CAI, Yu; DUAN, Jifeng
Patent: WO2011/137587 A1, 2011 ;
