(3S)-四氢-2H-吡喃-3-胺盐酸盐合成路线 （共 4 条）
反应条件
hydrogenchloride in methanol T=20°C;
参考文献
F. HOFFMANN-LA ROCHE AG; HURLEY, Christopher; KULAGOWSKI, Janusz; ZAK, Mark
Patent: WO2013/7768 A1, 2013 ;
Location in patent: Page/Page column 110; 111 ;
WO 2013/007768 A1
反应条件
1.1: chloro-trimethyl-silane / 0 - 20 °C 1.2: 25 °C 2.1: lithium borohydride / tetrahydrofuran / 16 h / 0 - 20 °C 2.2: 0 °C 3.1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 48 h / 20 °C 4.1: hydrogenchloride / methanol / 20 °C View Scheme
参考文献
Savage, Scott; Babu, Srinivasan; Zak, Mark; Mao, Zhongping; Cao, Jianhua; Ge, Yonghui; Ma, Dongxu; Jiang, Guoqiang
Synlett, 2013 , vol. 24, # 8 art. no. ST-2013-R0106-L, p. 987 - 990
反应条件
1.1: lithium borohydride / tetrahydrofuran / 16 h / 0 - 20 °C 1.2: 0 °C 2.1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 48 h / 20 °C 3.1: hydrogenchloride / methanol / 20 °C View Scheme
参考文献
Savage, Scott; Babu, Srinivasan; Zak, Mark; Mao, Zhongping; Cao, Jianhua; Ge, Yonghui; Ma, Dongxu; Jiang, Guoqiang
Synlett, 2013 , vol. 24, # 8 art. no. ST-2013-R0106-L, p. 987 - 990
反应条件
1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 48 h / 20 °C 2: hydrogenchloride / methanol / 20 °C View Scheme
参考文献
Savage, Scott; Babu, Srinivasan; Zak, Mark; Mao, Zhongping; Cao, Jianhua; Ge, Yonghui; Ma, Dongxu; Jiang, Guoqiang
Synlett, 2013 , vol. 24, # 8 art. no. ST-2013-R0106-L, p. 987 - 990
