反应条件
1: 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid ester With HATU in acetonitrile T=20°C; 1 h; 2: 6-amino-5-tert-butyl-3,3-dimethylbenzofuran-2(3H)-one With N-ethyl-N,N-diisopropylamine in acetonitrile T=20 - 45°C; Product distribution / selectivity;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; DEMATTEI, John; LOOKER, Adam, R.; NEUBERT-LANGILLE, Bobbianna; TRUDEAU, Martin; ROEPER, Stefanie; RYAN, Michael, P.; YAP, Dahrika, Milfred Lao; KRUEGER, Brian, R.; GROOTENHUIS, Peter, D.J.; VAN GOOR, Frederick, F.; BOTFIELD, Martyn, C.; ZLOKARNIK, Gregor
Patent: WO2010/108162 A1, 2010 ;
Location in patent: Page/Page column 75; 78-79 ;
