1-(2-氨基-3-氟-苯基)乙酮合成路线 （共 5 条）
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=20°C; P=760.051 Torr; 8 h; Inert atmosphere;
参考文献
H. LUNDBECK A/S; KEHLER, Jan; KILBURN, John Paul; NIELSEN, Jacob; PÜSCHL, Ask; LANGGÅRD, Morten; JESSING, Mikkel; MARIGO, Mauro
Patent: WO2013/50527 A1, 2013 ;
Location in patent: Page/Page column 42; 43; 44 ;
反应条件
methanol; sodium hydroxide T=20 - 80°C; 75 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/45861 A1, 2007 ;
Location in patent: Page/Page column 14; 75 ;
WO 2007/045861 A1
参考文献
Kabushiki Kaisha Yakult Honsha
Patent: US5061800 A1, 1991 ;
反应条件
1: magnesium / tetrahydrofuran; ethanol; tetrachloromethane / 3.5 h / 50 - 60 °C 2: hydrogen; palladium 10 on activated carbon / methanol / 8 h / 20 °C / 760.05 Torr / |Inert atmosphere View Scheme
参考文献
H. LUNDBECK A/S; KEHLER, Jan; KILBURN, John Paul; NIELSEN, Jacob; PÜSCHL, Ask; LANGGÅRD, Morten; JESSING, Mikkel; MARIGO, Mauro
Patent: WO2013/50527 A1, 2013 ;
反应条件
hydrogenchloride; iodine cloride in water
T=20°C; 2.55 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/45861 A1, 2007 ;
Location in patent: Page/Page column 14; 75-76 ;
WO 2007/045861 A1
