N-(叔丁氧羰基)-D-叔亮氨酸合成路线 （共 9 条）
反应条件
sodium hydroxide in methanol; water T=0 - 20°C;
参考文献
GLAXO GROUP LIMITED; ALVARO, Giuseppe; DECOR, Anne; FONTANA, Stefano; HAMPRECHT, Dieter; LARGE, Charles; MARASCO, Agostino
Patent: WO2011/69951 A1, 2011 ;
Location in patent: Page/Page column 77 ;
WO 2011/069951 A1
反应条件
1: (R)-α-N-benzyhydrylamino-tert-butyl-acetonitrile With hydrogenchloride; sulfuric acid in water T=120°C; 44 h; 2: With sodium hydroxide in water pH=11; 3: di-tert-butyl dicarbonate
参考文献
US2013/66109 A1, ;
Paragraph 0320; 0321; 0322 ;
反应条件
dipyridinium dichromate in N,N-dimethyl-formamide Ambient temperature;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 4 p. 1077 - 1079
反应条件
1: Et3N, DMAP / CH2Cl2 / 9 h / Ambient temperature 2: KMnO4, KOH / 2-methyl-propan-2-ol; H2O / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 53, # 4 p. 1275 - 1294
反应条件
1: Et3N, DMAP / CH2Cl2 / 9 h / Ambient temperature 2: KMnO4, KOH / 2-methyl-propan-2-ol; H2O / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 53, # 4 p. 1275 - 1294
反应条件
1.1: sodium sulfate / dichloromethane / 20 °C 2.1: toluene / 0.17 h / 0 °C / |Inert atmosphere 2.2: 0.42 h / 0 °C 3.1: hydrogenchloride; sulfuric acid / water / 44 h / 120 °C 3.2: pH 11 View Scheme
反应条件
sodium hydroxide in water
参考文献
Tetrahedron Asymmetry, , vol. 17, # 13 p. 1995 - 1999
反应条件
1.1: toluene / 0.17 h / 0 °C / |Inert atmosphere 1.2: 0.42 h / 0 °C 2.1: hydrogenchloride; sulfuric acid / water / 44 h / 120 °C 2.2: pH 11 View Scheme
反应条件
hydrogenchloride in 1,4-dioxane
参考文献
Agosta, Eleonora; Caligiuri, Antonio; D'Arrigo, Paola; Servi, Stefano; Tessaro, Davide; Canevotti, Renato
Tetrahedron Asymmetry, 2006 , vol. 17, # 13 p. 1995 - 1999
