1-氟-4-(2-丙炔-1-基氧基)苯合成路线 （共 4 条）
反应条件
1: 4-Fluorophenyl alcohol With potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.5 h; Inert atmosphere; 2: propargyl bromide in N,N-dimethyl-formamide T=20°C; 10 h; Inert atmosphere;
参考文献
Tsuzuki, Yasuhiro; Nguyen, Thao Kim Nu; Garud, Dinesh R.; Kuberan, Balagurunathan; Koketsu, Mamoru
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 24 p. 7269 - 7273
反应条件
potassium carbonate in acetonitrile T=20°C; 96 h;
参考文献
Schmidt, Robert G.; Bayburt, Erol K.; Latshaw, Steven P.; Koenig, John R.; Daanen, Jerome F.; McDonald, Heath A.; Bianchi, Bruce R.; Zhong, Chengmin; Joshi, Shailen; Honore, Prisca; Marsh, Kennan C.; Lee, Chih-Hung; Faltynek, Connie R.; Gomtsyan, Arthur
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1338 - 1341
反应条件
bis-triphenylphosphine-palladium(II) chloride; triethylamine in water; N,N-dimethyl-formamide T=80°C; 3 h;
参考文献
Pal, Manojit; Parasuraman, Karuppasamy; Yeleswarapu, Koteswar Rao
Organic Letters, 2003 , vol. 5, # 3 p. 349 - 352
反应条件
1: 1-fluoro-4-(prop-2-yn-1-yloxy)benzene With ethylmagnesium bromide in tetrahydrofuran T=0°C; Metallation; 2: acetaldehyde in tetrahydrofuran T=0°C; Grignard reaction;
参考文献
Luo, Fen-Tair; Ko, Seng-Li; Liu, Lijun; Chen, Hui
Heterocycles, 2000 , vol. 53, # 9 p. 2055 - 2066
