5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉-1-羧酸乙酯合成路线 (共 6 条)
反应条件
magnesium chloride in tetrahydrofuran; 2-methoxy-ethanol 6 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2003/76442 A1, 2003 ;
Location in patent: Page/Page column 24 ;
WO 03/076442 A1
反应条件
magnesium chloride in tetrahydrofuran; 2-methoxy-ethanol 6 h; Heating / reflux;
参考文献
Al-Awar, Rima Salim; Hecker, Kyle Andrew; Ray, James Edward; Huang, Jianping; Joseph, Sajan; Li, Tiechao; Paal, Michael; Rathnachalam, Radhakrishnan; Shih, Chuan; Waid, Philip Parker; Zhou, Xun; Zhu, Guoxin
Patent: US2003/229026 A1, 2003 ;
Location in patent: Page 15 ;
US 20030229026 A1
反应条件
1: tetrahydrofuran / 24 h / Ambient temperature 2: MgCl2 / 2-methoxy-ethanol; tetrahydrofuran / 6 h / 125 °C View Scheme
参考文献
Van Wijngaarden; Hamminga; Van Hes; Standaar; Tipker; Tulp; Mol; Olivier; De Jonge
Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3693 - 3699
反应条件
1: tetrahydrofuran / 24 h / Ambient temperature 2: MgCl2 / 2-methoxy-ethanol; tetrahydrofuran / 6 h / 125 °C View Scheme
参考文献
Van Wijngaarden; Hamminga; Van Hes; Standaar; Tipker; Tulp; Mol; Olivier; De Jonge
Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3693 - 3699
反应条件
1: 94 percent / aq. NaOH / ethanol / 2 h / Heating 2: 93 percent / copper chromite, quinoline / 3 h / 185 °C View Scheme
参考文献
Van Wijngaarden; Hamminga; Van Hes; Standaar; Tipker; Tulp; Mol; Olivier; De Jonge
Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3693 - 3699
反应条件
sodium hydroxide in ethanol 2 h; Heating;
参考文献
Van Wijngaarden; Hamminga; Van Hes; Standaar; Tipker; Tulp; Mol; Olivier; De Jonge
Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3693 - 3699