N-(三苯基甲基)-5-(4'-溴甲基联苯-2-基)四氮唑合成路线 （共 26 条）
反应条件
potassium carbonate in N,N-dimethyl acetamide
参考文献
Sankyo Company, Limited
Patent: US5616599 A1, 1997 ;
US 5616599 A
反应条件
1.1: potassium carbonate / toluene / 0.75 h / 45 - 50 °C 1.2: 10 h / 60 - 70 °C 2.1: diisopropylamine; sodium hydroxide / toluene; isobutyramide / 4 h / 25 - 45 °C 2.2: 8 h / 40 - 70 °C 2.3: 25 - 35 °C / pH ~ 6 - 7 View Scheme
参考文献
INTERQUIM, S.A.; JOVE MARTI, Iban; MARQUILLAS OLONDRIZ, Francisco
Patent: WO2012/55994 A1, 2012 ;
反应条件
1: N-alkylation of ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate With potassium carbonate in water; toluene T=45 - 65°C; 0.916667 h; Industry scale; 2: [2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl bromide With tetrabutylammomium bromide T=60 - 70°C; 10 h; Industry scale; 3: medoxomil chloride Product distribution / selectivity;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; KOLLA, Naveen Kumar; MANNE, Nagaraju; NAREDLA, Anitha; SHINDE, Sachin Gulabrao
Patent: WO2011/14611 A2, 2011 ;
Location in patent: Page/Page column 12; 13 ;
反应条件
1.1: sodium hydroxide / water; ethyl acetate / 0.33 h / pH 10 - 12 1.2: TTBB / 55 - 60 °C 1.3: 1 h 2.1: water; dichloromethane / pH 7 - 8 2.2: 0.5 h / -10 - -5 °C 2.3: -10 - -5 °C 3.1: N-ethyl-N,N-diisopropylamine; palladium 10 on activated carbon; hydrogen / methanol / 6 h / 2250.23 - 3750.38 Torr / |Autoclave View Scheme
参考文献
ALKEM LABORATORIES LTD.; RAO, Mahendranath Narasimha Rao; RAVILLA, Lokesh; KANAKAMAJALU, Shridhara; RAO, Sundarraja Kothapalli; NAGARAJAN, Kuppuswamy
Patent: WO2013/72924 A1, 2013 ;
反应条件
potassium carbonate in acetonitrile 7 h; Heating / reflux;
参考文献
KRKA
Patent: WO2007/17135 A2, 2007 ;
Location in patent: Page/Page column 5; 21 ;
反应条件
sodium hydroxide; tetrabutylammomium bromide in n-butyl chloride; water T=25 - 50°C; 32 h;
参考文献
WO2006/38223 A1, ;
Page/Page column 6-7 ;
