1.1: 60 percent / DEAD; PPh3 / tetrahydrofuran / 1 h / -20 - 25 °C 2.1: aq. NH3 / 1 h / 25 °C 2.2: 187 mg / aq. NaOH / dioxane / 1 h / 25 °C 3.1: 161 mg / DCC; 1-hydroxybenzotriazole; Et3N / CH2Cl2; tetrahydrofuran / 17 h / 25 °C 4.1: 90.1 percent / H2 / Pd / methanol; H2O / 4 h / 25 °C / 2574.28 Torr View Scheme

1.1: 60 percent / DEAD; PPh3 / tetrahydrofuran / 1 h / -20 - 25 °C 2.1: aq. NH3 / 1 h / 25 °C 2.2: 187 mg / aq. NaOH / dioxane / 1 h / 25 °C 3.1: 161 mg / DCC; 1-hydroxybenzotriazole; Et3N / CH2Cl2; tetrahydrofuran / 17 h / 25 °C 4.1: 90.1 percent / H2 / Pd / methanol; H2O / 4 h / 25 °C / 2574.28 Torr View Scheme

1.1: 60 percent / DEAD; PPh3 / tetrahydrofuran / 1 h / -20 - 25 °C 2.1: aq. NH3 / 1 h / 25 °C 2.2: 187 mg / aq. NaOH / dioxane / 1 h / 25 °C View Scheme

sodium hydroxide in 1,4-dioxane; water 1 h; Ambient temperature;