6-溴-2-哌嗪-1-基-喹啉合成路线 （共 3 条）
反应条件
1: dimethylformamide / 80 °C 2: 4 M aq. H2SO4 / 80 °C View Scheme
参考文献
WYETH
Patent: WO2004/24731 A1, 2004 ;
Location in patent: Page 50-51 ;
WO 2004/024731 A1
反应条件
1: 95 percent / aq. NaBrO3; HBr; AcOH / 0.33 h / 20 °C 2: POCl3; DDQ / dimethylformamide / 6 h / 20 °C 3: dimethylformamide / 80 °C 4: 4 M aq. H2SO4 / 80 °C View Scheme
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Byung Chul; Chi, Dae Yoon; Choe, Yearn Seong; Jeong, Kyung Ja; Jin, Changbae
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 14 p. 1559 - 1562
反应条件
1: POCl3; DDQ / dimethylformamide / 6 h / 20 °C 2: dimethylformamide / 80 °C 3: 4 M aq. H2SO4 / 80 °C View Scheme
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Byung Chul; Chi, Dae Yoon; Choe, Yearn Seong; Jeong, Kyung Ja; Jin, Changbae
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 14 p. 1559 - 1562
