hydrogen; palladium on activated charcoal

1.1: tetrahydrofuran / 24 h / 0 - 20 °C 2.1: water / tetrahydrofuran / 48 h 2.2: 4M hydrochloric acid / ethyl acetate / 24 h View Scheme

hydrogen; palladium on activated charcoal

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1209320', constants.ctx, '0')">sodium azide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />T=50&deg;C;&nbsp;Diazotization;&nbsp;stereogenic inversion;&nbsp;30&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: thionyl chloride / methanol / Heating<br />2: thionyl chloride / 2 h / Heating<br />3: triethylamine / CH₂Cl₂ / 0.17 h / 0 &deg;C<br />4: sodium azide / dimethylformamide / 30 h / 50 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: potassium bromide, sodium nitrite / H₂SO₄ / 1 h / 0 &deg;C<br />3: 1.) hemin copolymer 1, sodium azide / 1.) water, 12 h, 2.) benzene, 6 h, 60 deg C<br /> <br /> &nbsp;