1: With 5 alumina-supported palladium; hydrogen in N,N-dimethyl-formamide T=30°C; P=2942.29 Torr; 2: With hydrogenchloride in water T=10°C; pH=3 - 4;

hydrogenchloride; formic acid; palladium in water; acetone

hydrogenchloride in water; N,N-dimethyl-formamide; acetonitrile T=0 - 5°C; pH=2; 0.5 h; Product distribution / selectivity;

1: 3.5 g / 4-dimethylaminopyridine; DCC / dimethylformamide / 66 h / 20 °C 2: aq. HCl; hydrogen / palladium on charcoal / methanol; tetrahydrofuran / 18 h / 20 °C View Scheme

1: SIRC cell lysate; Dulbecco's Modified Phosphite-Buffer Saline / 34 °C / pH 7.4 2: 3.5 g / 4-dimethylaminopyridine; DCC / dimethylformamide / 66 h / 20 °C 3: aq. HCl; hydrogen / palladium on charcoal / methanol; tetrahydrofuran / 18 h / 20 °C View Scheme