反-N-(2-亚糠基乙酰)甘氨酸合成路线 （共 9 条）
参考文献
Jaffe; Cohn
Chemische Berichte, 1887 , vol. 20, p. 2312
反应条件
1: With dicyclohexyl-carbodiimide in 1,4-dioxane
Substitution; 24 h;
2: With sodium hydroxide
T=90°C; Hydrolysis; 1 h;
参考文献
Parkash, M. K.; Caldwell, J.
Food and Chemical Toxicology, 1994 , vol. 32, # 10 p. 887 - 896
反应条件
triethylamine in ethylene glycol dimethyl ether; water
T=20°C; 48 h;
参考文献
Katritzky, Alan R.; Gyanda, Reena; Meher, Nabin K.; Song, Yuming
Heterocycles, 2009 , vol. 77, # 2 p. 1249 - 1259
反应条件
carboxypeptidase from yeast (CPase-Y) in N,N-dimethyl-formamide
T=35°C; P=750060 Torr; 3 h; pH=6.5;
参考文献
Kunugi, Shigeru; Tanabe, Kazuo; Yamashita, Kouji; Morikawa, Yoshio; Ito, Takanobu; et al.
Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 2 p. 514 - 518
反应条件
water; thermolysin
T=24.8°C; pH 7.48; further (deuterized substrate) and solvent (D2O); β-deuterium isotope effects, solvent isotope isotope effects; Rate constantMechanism;
参考文献
Stein, Ross L.
Journal of the American Chemical Society, 1988 , vol. 110, # 23 p. 7907 - 7908
反应条件
1: 69 percent / BOP; EtN(iPr)2 / CH2Cl2 / 12 h / 20 °C
2: 84 percent / aq. NaOH / dioxane / 12 h / 20 °C
View Scheme
参考文献
Michel Brunel, Jean; Salmi, Chanaz; Letourneux, Yves
Tetrahedron Letters, 2005 , vol. 46, # 2 p. 217 - 220
反应条件
carboxypeptidase Y
T=25°C; biochem. proc.; pH = 7;
参考文献
Kunugi, Shigeru; Tanabe, Kazuo; Yamashita, Kouji; Fukuda, Mitsuhiro
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 4 p. 1399 - 1402
反应条件
1: 38.1 percent Spectr. / carboxypeptidase from yeast (CPase-Y) / dimethylsulfoxide / 3 h / 30 °C / 750060 Torr
2: 68.5 percent Spectr. / carboxypeptidase from yeast (CPase-Y) / dimethylformamide / 3 h / 35 °C / 750060 Torr / pH=6.5
View Scheme
参考文献
Kunugi, Shigeru; Tanabe, Kazuo; Yamashita, Kouji; Morikawa, Yoshio; Ito, Takanobu; et al.
Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 2 p. 514 - 518
参考文献
Sasaki
Biochemische Zeitschrift, 1910 , vol. 25, p. 274
