2-甲氧基-5-甲基-N,N-双(1-甲基乙基)-gamma-苯基-苯丙胺富马酸盐合成路线 （共 14 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol P=2068.65 - 3102.97 Torr;
参考文献
WO2007/39918 A1, ;
Page/Page column 17 ;
反应条件
1: With sodium tris(acetoxy)borohydride in tetrahydrofuran Reductive amination; 2 h; 2: With water; sodium hydrogencarbonate in tetrahydrofuran
参考文献
EP1698615 A1, ;
Page/Page column 9-10 ;
EP 1698615 A1
反应条件
in acetonitrile T=90°C; Autoclave;
参考文献
WO2010/46801 A2, ;
Page/Page column 18; 10 ;
反应条件
hexylmethylimidazolium tetrafluoroborate T=50 - 80°C; 24.25 h;
参考文献
US2006/79716 A1, ;
Page/Page column 8 ;
反应条件
thionyl chloride; diisopropylamine in dichloromethane; water
参考文献
US5382600 A1, ;
US 5382600 A
反应条件
sodium hydroxide; acetic acid in dichloromethane; water pH=9.5; 0.75 h;
参考文献
EP1927585 A2, ;
Page/Page column 11 ;
反应条件
1: (2-methoxy-5-methylphenyl)phenylmethane; 3-benzyl-4-methylanisole With n-butyllithium in tetrahydrofuran T=-78 - 0°C; 6 h; 2: 1-diisopropylamino-2-chloroethane in tetrahydrofuran T=-78 - 20°C; 2 h; Product distribution / selectivity;
参考文献
US7268257 B1, ;
Page/Page column 9; 9-10 ;
反应条件
hydrogen bromide in water; acetic acid T=110 - 115°C; 10 - 12 h;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2004/78700 A1, 2004 ;
Location in patent: Page 8-9 ;
反应条件
water; hydrogen bromide; tetrabutylammomium bromide in acetic acid T=115°C; 48 h; Heating / reflux; Product distribution / selectivity;
参考文献
Ragactives, S.L.
Patent: EP1698615 A1, 2006 ;
Location in patent: Page/Page column 10 ;
EP 1698615 A1
