2-[3-(二异丙胺基)-1-苯丙基l]-4-甲基苯酚合成路线 （共 23 条）
反应条件
hydrogen; palladium hydroxide on carbon in methanol; toluene T=110°C; P=4654.46 Torr; 48 h;
参考文献
WO2007/138440 A1, ;
Page/Page column 11-12; 13-14 ;
反应条件
1: With hydrogen bromide; acetic acid in water T=110 - 115°C; 2: With sodium hydroxide
参考文献
WO2010/46801 A2, ;
Page/Page column 19; 10 ;
反应条件
sodium hydroxide in acetone T=0 - 4°C; pH=11.1; 1.5 h;
参考文献
WO2007/46001 A2, ;
Page/Page column 12 ;
反应条件
1: With sulfuric acid in water T=20°C; 3 h; 2: With sodium hydroxide in water T=0°C; pH=9 - 10; 0.5 h;
参考文献
US2006/189827 A1, ;
Page/Page column 6 ;
反应条件
perchloric acid in dichloromethane; water T=20°C; 3 h;
参考文献
Synthesis, , # 12 art. no. F03308SS, p. 1841 - 1844
反应条件
1: With sodium hydroxide in water 2: in hexane T=0 - 5°C; 3 h;
参考文献
EP1810962 A1, ;
Page/Page column 3-4 ;
反应条件
1: With toluene-4-sulfonic acid; acetic acid T=50 - 100°C; 8.5 h; 2: in water; toluene pH=9 - 10;
参考文献
EP1927585 A2, ;
Page/Page column 10 ;
反应条件
1: With water; hydrogen bromide; acetic acid 3 h; Heating / reflux; 2: With sodium hydroxide; sodium carbonate in water pH=11;
参考文献
US7268257 B1, ;
Page/Page column 10 ;
反应条件
1: With lithium aluminium tetrahydride in diethyl ether 96 h; Heating / reflux; 2: With water; acetic acid in diethyl ether pH=5; Product distribution / selectivity;
参考文献
US2006/189827 A1, ;
Page/Page column 5 ;
反应条件
1: With boron tribromide in dichloromethane Inert atmosphere; 2: With sodium hydroxide in dichloromethane; water T=30 - 35°C; 0.5 h; Product distribution / selectivity;
参考文献
US2012/41235 A1, ;
Page/Page column 5 ;
