3-(2-甲氧基-5-甲基苯基)-3-苯基-1-丙醇合成路线 （共 6 条）
反应条件
1: With n-butyllithium in tetrahydrofuran T=-78 - 20°C; 4 h; 2: With water; ammonium chloride in tetrahydrofuran
参考文献
Ragactives, S.L.
Patent: EP1698615 A1, 2006 ;
Location in patent: Page/Page column 9 ;
EP 1698615 A1
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran T=20°C; 2: With methanesulfonic acid in tetrahydrofuran T=20 - 70°C; Product distribution / selectivity;
参考文献
ALEMBIC LIMITED; PONNAIAH, Ravi; DESAI, Sanjay; SHAH, Chankrakant Chunilal; PATEL, Kalpesh Shantibhai; PAREKH, Viral Maheshbhai
Patent: WO2010/46801 A2, 2010 ;
Location in patent: Page/Page column 16 ;
反应条件
1: potassium carbonate / methanol / 10 h / 55 - 60 °C 2: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 3 h / -5 - 5 °C / Inert atmosphere View Scheme
反应条件
1.1: triethylamine / dichloromethane / 3 h / 0 - 10 °C / Inert atmosphere 2.1: sodium iodide / acetonitrile / 4 h / 100 °C / Autoclave 2.2: Inert atmosphere 3.1: boron tribromide / dichloromethane / Inert atmosphere 3.2: 0.5 h / 30 - 35 °C View Scheme
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
ALEMBIC LIMITED; PONNAIAH, Ravi; DESAI, Sanjay; SHAH, Chankrakant Chunilal; PATEL, Kalpesh Shantibhai; PAREKH, Viral Maheshbhai
Patent: WO2010/92500 A2, 2010 ;
Location in patent: Paragraph 166-173 ;
反应条件
1: With triethylamine in dichloromethane
T=0 - 20°C; 20 h;
2: in dichloromethane; water
T=0°C;
参考文献
CHEMI SPA
Patent: US2006/79716 A1, 2006 ;
Location in patent: Page/Page column 7-8 ;
