4-(2-喹啉基甲氧基)苯酚合成路线 （共 8 条）
反应条件
sodium hydroxide in methanol; water
T=10 - 50°C; 3.25 h; Inert atmosphere;
参考文献
Bridge, Andrew W.; Jones, Ronald H.; Kabir, Humayun; Kee, Alex A.; Lythgoe, David J.; Nakach, Mustafa; Pemberton, Clive; Wrightman, John A.
Organic Process Research and Development, 2001 , vol. 5, # 1 p. 9 - 15
反应条件
p-methylbenzenesulfonyl (tosylate); potassium carbonate in methanol; acetonitrile
T=65°C; 2 h; Yields of byproduct given;
参考文献
O'Brien; Sledeski; Truesdale
Tetrahedron Letters, 1997 , vol. 38, # 4 p. 509 - 512
参考文献
Aventis Pharma Deutschland GmbH
Patent: US7005440 B1, 2006 ;
Location in patent: Page/Page column 222-223 ;
US 7005440 B1
反应条件
1: 76 percent / K2CO3 / acetone; dimethylformamide / 48 h / Heating
2: 63 percent / NaOC2H5 / ethanol / 2 h / Heating
View Scheme
参考文献
Youssefyeh; Magnien; Lee; Chan; Lin; Galemmo Jr.; Johnson Jr.; Tan; Campbell; Huang; Nuss; Carnathan; Sutherland; Van Inwegen
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1186 - 1194
反应条件
1: 76 percent / K2CO3 / acetone; dimethylformamide / 48 h / Heating
2: 63 percent / NaOC2H5 / ethanol / 2 h / Heating
View Scheme
参考文献
Youssefyeh; Magnien; Lee; Chan; Lin; Galemmo Jr.; Johnson Jr.; Tan; Campbell; Huang; Nuss; Carnathan; Sutherland; Van Inwegen
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1186 - 1194
反应条件
sodium hydroxide in methanol; acetonitrile
参考文献
Sledeski, Adam W.; O'Brien, Michael K.; Truesdale, Larry K.
Tetrahedron Letters, 1997 , vol. 38, # 7 p. 1129 - 1132
反应条件
1.1: Na2CO3*H2O; sodium carbonate / 35 °C
1.2: 3 h / 35 - 40 °C
2.1: sodium hydroxide / water; methanol / 3.25 h / 10 - 50 °C / |Inert atmosphere
View Scheme
参考文献
Bridge, Andrew W.; Jones, Ronald H.; Kabir, Humayun; Kee, Alex A.; Lythgoe, David J.; Nakach, Mustafa; Pemberton, Clive; Wrightman, John A.
Organic Process Research and Development, 2001 , vol. 5, # 1 p. 9 - 15
反应条件
1: KF*alumina / acetonitrile / 5 h / 50 °C
2: HCl / methanol
View Scheme
参考文献
Sledeski, Adam W.; O'Brien, Michael K.; Truesdale, Larry K.
Tetrahedron Letters, 1997 , vol. 38, # 7 p. 1129 - 1132
