1: With sodium azide; acetic acid; triethylamine T=60 - 130°C; 7 h; Inert atmosphere; 2: With sodium hydroxide in water T=80°C; 0.25 h; Inert atmosphere; SolventReagent/catalyst;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '19255076', constants.ctx, '0')">Adogen phase-transfer catalyst</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '635760', constants.ctx, '0')">toluene</a> <br />48&nbsp;h;&nbsp;&nbsp;Heating;&nbsp;<br /> &nbsp;

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<b>Multi-step reaction with 3 steps<br /> </b>1.1: Na₂CO₃*H₂O; sodium carbonate / 35 &deg;C<br />1.2: 3 h / 35 - 40 &deg;C<br />2.1: sodium hydroxide / water; methanol / 3.25 h / 10 - 50 &deg;C / |Inert atmosphere<br />3.1: sodium hydroxide / water; isopropyl alcohol / 2.5 h / 50 - 60 &deg;C / |Inert atmosphere<br />3.2: 4 h / 84 &deg;C / |Inert atmosphere<br /> <br /> &nbsp;