(2S)-2-[[(1,1-二甲基乙氧基)羰基]氨基]-4-氧代-丁酸苯甲酯合成路线 （共 4 条）
反应条件
oxalyl dichloride; dimethyl sulfoxide in dichloromethane
T=-78°C; Swern oxidation; 0.5 h;
参考文献
Wang, Qun; Linhardt, Robert J.
Journal of Organic Chemistry, 2003 , vol. 68, # 7 p. 2668 - 2672
反应条件
1: With pyridine; oxalyl dichloride; N,N-dimethyl-formamide in tetrahydrofuran; acetonitrile
T=-30°C; 1 h; Inert atmosphere;
2: With lithium tri-t-butoxyaluminum hydride in tetrahydrofuran; acetonitrile
T=-78°C; 0.5 h; Inert atmosphere;
参考文献
Brasile, Giuseppina; Mauri, Laura; Sonnino, Sandro; Compostella, Federica; Ronchetti, Fiamma
Amino Acids, 2013 , vol. 44, # 2 p. 435 - 441
反应条件
1: 2.63 g / aq. KOH / 1.) DMF, 0 deg C, 1 h then rt., 2 h; 2.) 18-crown-6, rt., 18 h
2: 82 percent / (COCl)2, DMSO, Et3N / CH2Cl2 / 2 h / -78 - 0 °C
View Scheme
参考文献
Matsuura; Hamada; Shioiri
Tetrahedron, 1994 , vol. 50, # 1 p. 265 - 274
反应条件
1: 2.63 g / aq. KOH / 1.) DMF, 0 deg C, 1 h then rt., 2 h; 2.) 18-crown-6, rt., 18 h
2: 82 percent / (COCl)2, DMSO, Et3N / CH2Cl2 / 2 h / -78 - 0 °C
View Scheme
参考文献
Matsuura; Hamada; Shioiri
Tetrahedron, 1994 , vol. 50, # 1 p. 265 - 274
