1.1: trans-1,2-cyclohexanediamine; potassium carbonate; copper(l) chloride / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere; Darkness 2.1: 7 h / 23 °C 2.2: 23 °C View Scheme

trans-1,2-cyclohexanediamine; potassium carbonate; copper(l) chloride in 1,4-dioxane T=110°C; 15 h; Inert atmosphereDarkness;

Multi-step reaction with 2 steps 1.1: [Ni0(1,5-cyclooctadiene)2]; sodium t-butanolate; 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere2.1: N-iodo-succinimide; trifluoroacetic acid / 14 h / 23 °C / Inert atmosphere2.2: 23 °C  

Multi-step reaction with 4 steps 1.1: Inert atmosphere2.1: Inert atmosphere3.1: [Ni0(1,5-cyclooctadiene)2]; sodium t-butanolate; 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere4.1: N-iodo-succinimide; trifluoroacetic acid / 14 h / 23 °C / Inert atmosphere4.2: 23 °C