3-(哌啶-4-基)氮杂丁烷-1-羧酸叔丁酯合成路线 （共 5 条）
反应条件
hydrogen; palladium(II) oxide hydrate in ethanol T=20°C; P=2585.81 Torr; 96 h; Inert atmosphere;
参考文献
Connolly, Peter J.; Bian, Haiyan; Li, Xun; Liu, Li; Macielag, Mark J.; McDonnell, Mark E.
Patent: US2013/102584 A1, 2013 ;
Location in patent: Paragraph 0289; 0294 ;
反应条件
1: sodium tetrahydroborate; sodium hydrogencarbonate / ethanol / 1.17 h / 0 - 20 °C / |Inert atmosphere 2: hydrogen; palladium(II) oxide hydrate / ethanol / 96 h / 20 °C / 2585.81 Torr / |Inert atmosphere View Scheme
参考文献
Connolly, Peter J.; Bian, Haiyan; Li, Xun; Liu, Li; Macielag, Mark J.; McDonnell, Mark E.
Patent: US2013/102584 A1, 2013 ;
反应条件
1: acetonitrile / 1 h / 80 °C / |Inert atmosphere 2: sodium tetrahydroborate; sodium hydrogencarbonate / ethanol / 1.17 h / 0 - 20 °C / |Inert atmosphere 3: hydrogen; palladium(II) oxide hydrate / ethanol / 96 h / 20 °C / 2585.81 Torr / |Inert atmosphere View Scheme
参考文献
Connolly, Peter J.; Bian, Haiyan; Li, Xun; Liu, Li; Macielag, Mark J.; McDonnell, Mark E.
Patent: US2013/102584 A1, 2013 ;
反应条件
1.1: zinc; ethylene dibromide; chloro-trimethyl-silane / N,N-dimethyl acetamide / 1.5 h / 20 - 65 °C / |Inert atmosphere 1.2: 2 h / 80 °C / |Inert atmosphere 2.1: acetonitrile / 1 h / 80 °C / |Inert atmosphere 3.1: sodium tetrahydroborate; sodium hydrogencarbonate / ethanol / 1.17 h / 0 - 20 °C / |Inert atmosphere 4.1: hydrogen; palladium(II) oxide hydrate / ethanol / 96 h / 20 °C / 2585.81 Torr / |Inert atmosphere View Scheme
参考文献
Connolly, Peter J.; Bian, Haiyan; Li, Xun; Liu, Li; Macielag, Mark J.; McDonnell, Mark E.
Patent: US2013/102584 A1, 2013 ;
反应条件
1.1: zinc; ethylene dibromide; chloro-trimethyl-silane / N,N-dimethyl acetamide / 1.5 h / 20 - 65 °C / |Inert atmosphere 1.2: 2 h / 80 °C / |Inert atmosphere 2.1: acetonitrile / 1 h / 80 °C / |Inert atmosphere 3.1: sodium tetrahydroborate; sodium hydrogencarbonate / ethanol / 1.17 h / 0 - 20 °C / |Inert atmosphere 4.1: hydrogen; palladium(II) oxide hydrate / ethanol / 96 h / 20 °C / 2585.81 Torr / |Inert atmosphere View Scheme
参考文献
Connolly, Peter J.; Bian, Haiyan; Li, Xun; Liu, Li; Macielag, Mark J.; McDonnell, Mark E.
Patent: US2013/102584 A1, 2013 ;
