2-甲酰基吡啶-4-羧酸甲酯合成路线 （共 4 条）
反应条件
1: With Dess-Martin periodane in dichloromethane T=20°C; 2.5 h; 2: With sodium hydrogencarbonate in dichloromethane; water T=20°C; 0.25 h;
参考文献
ASTRAZENECA AB; CHENG, Leifeng; SCHELL, Peter
Patent: WO2012/47156 A1, 2012 ;
Location in patent: Page/Page column 12-13 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-60°C; 1.33333 h;
参考文献
Luo, Guanglin; Chen, Ling; Civiello, Rita; Pin, Sokhom S.; Xu, Cen; Kostich, Walter; Kelley, Michelle; Conway, Charles M.; MacOr, John E.; Dubowchik, Gene M.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2917 - 2921
反应条件
1: (NH4)2S2O8; sulfuric acid / water / 0.67 h / Reflux 2: Dess-Martin periodane / dichloromethane / 2.5 h / 20 °C View Scheme
参考文献
ASTRAZENECA AB; CHENG, Leifeng; SCHELL, Peter
Patent: WO2012/47156 A1, 2012 ;
反应条件
1: With diethylamino-sulfur trifluoride in dichloromethane T=0 - 20°C; 2 h; 2: With sodium hydrogencarbonate in dichloromethane; water T=0°C;
参考文献
AstraZeneca AB
Patent: US2010/261755 A1, 2010 ;
Location in patent: Page/Page column 35 ;
